Phosphogluconate dehydratase
| phosphogluconate dehydratase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| EC number | 4.2.1.12 | ||||||
| CAS number | 9024-33-3 | ||||||
| Databases | |||||||
| IntEnz | IntEnz view | ||||||
| BRENDA | BRENDA entry | ||||||
| ExPASy | NiceZyme view | ||||||
| KEGG | KEGG entry | ||||||
| MetaCyc | metabolic pathway | ||||||
| PRIAM | profile | ||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||
| Gene Ontology | AmiGO / EGO | ||||||
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In enzymology, a phosphogluconate dehydratase (EC 4.2.1.12) is an enzyme that catalyzes the chemical reaction
- 6-phospho-D-gluconate
2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O
Hence, this enzyme has one substrate, 6-phospho-D-gluconate, and two products, 2-dehydro-3-deoxy-6-phospho-D-gluconate and H2O.
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming). Other names in common use include 6-phosphogluconate dehydratase, 6-phosphogluconic dehydrase, gluconate-6-phosphate dehydratase, gluconate 6-phosphate dehydratase, 6-phosphogluconate dehydrase, and 6-phospho-D-gluconate hydro-lyase. This enzyme participates in Entner–Doudoroff pathway.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2GP4.